VPH0062N_Application Note Koffein MCSGP

Application Note ► Purifying common light-chain bispecific antibodies using MCSGP

In this application note the purification of a common light-chain bispecific antibody using Multicolumn countercurrent solvent gradient purification (MCSGP) is described. The KNAUER Contichrom® system that is offered in cooperation of KNAUER and Chromacon is the only system on the market that can be used in MCSGP mode for difficult bioseparations. MCSGP is a countercurrent chromatographic proce...

Application Note ► Separation of PEGylated proteins using MCSGP

Application Note ► Separation of three proteins using MCSGP

Dynamic Process Control (MControl®) for Countercurrent Polish Processes (MCSGP)

The Contichrom® CUBE Combined and Contichrom HPLC systems use batch and continuous periodic countercurrent (PCC) processes for purification of target proteins, peptides, and small molecules. Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) is a unique PCC polishing process that provides superior yield and purity at high productivity. In order to keep the MCSGP process at an opti...

Evaluation of the Financial Impact of Continuous Chromatography in the Production of Biologics

The primary goal of this internship is to explore the financial impact of changing one or more of the downstream chromatography steps involved in the purification of a complex biologic molecule from a batch process to a continuous one. This is particularly relevant, as biologics represent the fastest growing segment of the human therapeutics market, and, consequently, have become a major compon...